Cornell University recently published a new study on diabetes treatment at Diabetes, which allowed rats to take modified GLP-1-producing lactobacilli with unexpected hypoglycemic effects.
Glucogan-Like Peptide-1 (GLP-1) is a hormone produced mainly by intestinal epithelial cells and belongs to an incretin. It is known that GLP-1 has many physiological functions including promoting islet B cells to secrete insulin, inhibiting islet alpha cells secreting glucagon and the like. Its special physiological role has been a hot spot in diabetes research because it contributes to the treatment of diabetes.
Previous studies have shown that an inactive form of GLP-1, GLP-1 (1-37), stimulates the conversion of rat intestinal and human intestinal epithelial cells to islet B cells. So the research team at Cornell University wants to try whether GLP-1 (1-37), which is taken up by taking it, can re-encode the intestinal epithelial cells of diabetic rats and turn them into islet B cells to reduce hyperglycemia. symptom. They transferred the vector containing GLP-1 (1-37) to human lactobacilli and then orally administered the probiotic tablets to diabetic rats daily. The results are very obvious: after taking the rats, the amount of insulin secretion and tolerance to blood glucose increased significantly; many insulin-secreting cells appeared in the upper part of the small intestine, the number is equivalent to 25~33% of normal rat islet B cells; and these new insulin-secreting cells The expression of transcription factors MafA, PDX-1, and FoxA2 specific to islet B cells was detected. This means that these cells are very similar to B cells. The researchers also said that taking this lactobacillus in normal rats had no effect on blood glucose levels, as normal rats did not require extra insulin to maintain blood sugar levels.
The results of this study provide a safe and effective alternative to oral medications for the treatment of diabetes in the future. In fact, this technology has been licensed for production. Perhaps in the near future, diabetics will only need to take a probiotic tablet every morning to help control blood sugar. (Bio Valley Bioon.com)
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