When a heart attack occurs, certain nerve cells in the heart wall and special cells that keep the heart beating will be damaged, and surgery cannot repair this damaged area. According to a report by the American Physicists Organization Network on May 19th, recently, Brown University and Indian Institute of Technology engineers worked together to create an artificial nano-patch for the heart, which has been experimentally shown to cause damage to the area caused by the heart attack Recovery function. The research was published in the recently published "Journal of Biomaterials".
This artificial nano-patch is a scaffold-like structure composed of carbon nanotube fibers and an officially approved polymer material. The researchers used a spiral carbon nanotube fiber with a diameter of about 200 nanometers, and then used a high-molecular lactic glycolytic acid polymer to weave the fiber into a circular network with a diameter of 22 mm and a thickness of about 15 microns. Nano patch.
Experiments have shown that this artificial nano-patch can regenerate natural heart tissue cells (cardiomyocytes) and nerve cells, and rejuvenate the damaged area above the heart. The researchers cultured cardiomyocytes on the nanopatches. After 4 hours, the cardiomyocytes on the surface increased a lot, which was 5 times longer than the control sample material (made of polymer alone). After 5 days, the surface density of cardiomyocytes was 6 times that of the control sample. Nerve cell density also doubled after 4 days.
Thomas Webster, co-author of the thesis and associate professor of engineering and plastic surgery at Brown University, said that carbon nanotube fiber braided stents are flexible and durable, can expand and contract like heart tissue, so myocardial cells and nerve cells can produce new Cells to regenerate the injured part of the heart. Moreover, carbon nanotubes have excellent electrical conductivity and can function well as a connection circuit on which the heart beats steadily. This material can even be used to create a healthy heart in the future.
The researchers next will improve the shape of the stent to better simulate heart currents and create an internal test tube model to test the material's response to heart pressure and beating rhythm. In addition, whether the cardiomyocytes grown on the scaffold have the same function as other cardiac tissue cells needs further confirmation.
According to a survey by the American Heart Association, about 785,000 patients had another heart attack in 2009 due to myocardial damage caused by previous heart disease. Among people with a history of heart disease, 1/3 of women and 1/5 of men may relapse again in the next 6 years. If this method succeeds, millions of people will benefit from it.
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