Peking University Xi Zhenfeng was invited to summarize the work of metal heterocyclic reagents in the laboratory in the past ten years

Xi Zhenfeng, born in Henan Province, born in 1967, is currently a specially appointed professor, doctoral tutor, and Yangtze River scholar at the School of Chemistry of Peking University. The main research direction is to use metal-organic compounds to study new reactions and new methods for highly selective organic synthesis. Committed to studying the selective cleavage and recombination reaction of carbon-hydrogen bonds, carbon-carbon bonds and carbon-heteroatom bonds, and exploring the transformation of new generation materials. He has published many papers in famous journals such as J. Am. Chem. Soc.

In 2010, Xi Zhenfeng was invited to systematically summarize the double (lithium) metal organic reagents discovered and developed by the laboratory in the top international chemistry journal "Acc. Chem. Res.", And elaborated the concept of "synergistic effect" of the double metal organic reagents. And the new types of reactions and new methods of synthetic chemistry (Zhenfeng Xi, * 1,4-Dilithio-1,3-dienes: Reaction and Synthetic Applications, Acc. Chem. Res. 2010, 43, 1342-1451).

Recently, Xi Zhenfeng was invited again to systematically summarize the work of the laboratory in the research of metal heterocyclic reagents in the past decade (Wen-Xiong Zhang, Shaoguang Zhang, and Zhenfeng Xi, * Zirconocene and Si-tethered) on Acc. Chem. Res. Diynes: A Happy Match Directed towards Organometallic Chemistry and Organic Synthesis, Acc. Chem. Res. 2011, 44, 541-551). This article elaborated on the "synergistic effect" between some metal organic active intermediates and substrates, as well as the laboratory's research philosophy of "based on mechanism research and synthetic chemistry of active intermediates".

This series of work studies found that metal organic active intermediates can undergo a variety of unexpected structural changes under the coordination of ligands, similar to a "Chemical Transformer", which realizes metal organic active intermediates The selective cleavage and reorganization of the chemical bonds in the middle generate new metal organic compounds and cyclic organic compounds with various structures that cannot be synthesized by other methods.

Metal organic compounds are widely used as synthetic reagents in various fields related to synthetic chemistry, and have been greatly concerned by academia and industry. The Xi Zhenfeng group has carried out innovative and systematic work in the design and synthesis, structure and bonding mode, reaction and application of bimetallic organic synthesis reagents and metal heterocyclic reagents for more than ten years.

Organometallic compounds are also called metallo-organic compounds. The compound of alkyl (including methyl, ethyl, propyl, butyl, etc.) and aromatic (phenyl, etc.) hydrocarbon groups combined with metal atoms, and the general term for substances in which carbon element is directly combined with metal atoms. With lithium, sodium, magnesium, calcium, zinc, cadmium, mercury, beryllium, aluminum, tin, lead and other metals can form a more stable organometallic compound. It can be roughly divided into two types: alkylmetalic compounds and arymetalic compounds.

For the environment, the former is methylmercury compounds, tetraethyl lead, tributyltin; the latter is phenylmercury salts, triphenyltin, etc .; there are also organic manganese compounds such as tricarbonyl for gasoline antiknock Cyclopentadiene manganese, etc. Most of these substances are artificially synthesized, but lead, mercury, cadmium, tin, etc. will be methylated (or alkylated) in nature, such as conversion from inorganic mercury to methyl mercury. Most of them are due to the action of microorganisms in the sediment of the water body, and are transformed by various organisms in the fish body. Generally, organometallic compounds are fat-soluble and easier to pass through biofilms than inorganic metals, absorb through the intestinal wall, and enter the cerebral blood vessels and placenta more; therefore, they have stronger biological toxicity. Metal alkyl compounds are likely to cause central nervous system disorders. In the body, the microsomal drug metabolic enzyme system mainly composed of liver and other organs deorganizes the organometallic compound and removes the alkyl group and aromatic group, and finally becomes an inorganic metal. Birds are the most sensitive to toxicity caused by biological membranes.

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