Recently, the incident of excessive chromium content in capsules has become a hot spot reported by major media, and many domestic pharmaceutical manufacturers have been disclosed that the chromium content in capsules has seriously exceeded the standard. In China, the market for medical hollow capsules is very large. Only in Ru'ao Town, Xinchang County, Zhejiang Province, the annual output of capsules is hundreds of billions of capsules. The main component of the capsule is gelatin, and the price difference between high-quality gelatin and industrial gelatin is more than three times. In some pharmaceutical factories, the procurement department will purchase industrial gelatin to replace food-grade gelatin, and the quality inspection department of most pharmaceutical factories has not determined heavy metals. The chromium method, the 2010 edition of the Pharmacopoeia, only requires the determination of the total amount of heavy metals. Chromium is a sensitizing source. Hexavalent chromium is irritating and corrosive. Oral administration can irritate and corrode the digestive tract, causing nausea, vomiting, abdominal pain, bloody stools, etc. In severe cases, dyspnea, cyanosis, shock, liver damage and acute Renal failure, etc. The medicine contains high content of heavy metal chromium, which seriously threatens the health of patients!
How to analyze the chromium content more accurately? How to determine whether the inferior capsules with excessive chromium content have been used on the production line through analysis technology?
As the only international analytical instrument company covering all kinds of different ion analysis technologies in the world today, Metrohm has been paying close attention to social issues related to human health and the environment. In view of the excessive content of chromium in domestic capsules, Metrohm recommends the voltammetric polarography method: using 797 voltammetry, HMDE mode, and oxygen bomb combustion to process the sample. This method not only simplifies sample preparation. The sensitivity of the instrument itself for measuring chromium can be as high as ppb or even ppt chromium content. The result is high recovery rate, good reproducibility and easy operation. Voltammetric polarography is very accurate for measuring the content of chromium, which is suitable for the study of standard methods of chromium content in capsules.
Related report download: Measurement of trace chromium
About Metrohm:
In 1950, Metrohm invented the first compound pH electrode.
In 1954, Metrohm designed the first practical automatic polarograph for trace analysis.
In 1956, Metrohm developed the first piston-type burette.
In 1968, the world's first digital titrator and the first digital electronic burette were born in Metrohm, Switzerland.
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In 2007, Metrohm developed the first intelligent ion chromatograph.
In 2010, Metrohm developed the world's first ultraviolet ion chromatography.
Metrohm-Metrohm is the only international analytical instrument company in the world that covers all kinds of different ion analysis technologies.
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