Application of pharmaceutical packaging printing materials

At present, due to the rapid replacement of pharmaceutical packaging materials, old packaging materials have gradually been eliminated, such as the packaging of glass medicines, medicine packaging of iron containers, and paper bag packaging. The new pharmaceutical packaging has been put into the market in large quantities, such as blister packaging for pharmaceutical packaging, flexible packaging plastic film (bags) for proprietary Chinese medicines, and aluminum-plastic composite films.

After the aluminum foil for pharmaceutical packaging is heat-pressed with PVC (polyvinyl chloride) or PVDC (polyvinylidene chloride), it is a blister soft package for pharmaceuticals. The packaging that can be used as a drug after printing can develop rapidly in recent years. Some foreign institutions, such as the Flexible Packaging Assn., predict that “in the next five years, pharmaceutical flexible packaging will be the new economic growth point for the packaging market. In addition to the strong momentum for the development of medical products, it is possible to control the dose of thermoforming. Squeezed blister packaging (replacement of bulk or bottled drug packaging) will grow rapidly.” In our country's recent market survey results show that in the next 5 years, blister and pharmaceutical flexible packaging materials will still be 5% to 10% of the year The average growth rate exceeds the growth rate of 3% per year of pharmaceutical products. This is mainly because China is changing the form of solid packaging pharmaceutical packaging materials, from the early use of glass bottles, paper bags into plastic printing blister packaging; Chinese medicine granules, powders, powders, capsules are also transformed into Plastic composite film, aluminum plastic composite flexible packaging. This article will introduce the performance, characteristics and application range of this kind of new pharmaceutical packaging printing materials.

1 Blister packaging printing material characteristics and applications

Pharmaceutical blister packs are also known as blister packs, or PTP (Press Through Package). The packaging form of this medicine has a variety of advantages: it provides the patient with a single dose of medicine packaging method, which can be manually torn, which is convenient and economical; the aluminum foil for blister packaging can be printed into various colors and there are methods for taking medicines Drug issuers can avoid the occurrence of wrong-dosing drugs and mixed drugs in the distribution of multiple tablets; blister packaging has good protection performance, excellent drug resistance and chemical stability; production speed is quick and costs are relatively low; Small space, light weight, convenient transportation; good safety performance.
Medicinal blister printing and packaging materials include aluminum foil, plastic hard sheets, and heat seal coatings. Aluminum foil is a sealing material that is sealed on a plastic hard sheet, and is also called a cover material. It uses industrial pure aluminum as the base material, and has excellent properties such as non-toxic, corrosion-resistant, non-permeable, moisture-proof, moisture-proof, light-blocking and high-temperature sterilization; it also has good printing adaptability, and both sides can print text patterns. The thickness of the aluminum foil used for printing is usually between 0.021 and 0.027 mm and consists of an aluminum foil layer, a printing ink layer, a protective layer, and an adhesive layer.

Because the drug is very sensitive to moisture and light transmission, the blister printing material used requires high barrier properties to water, gas, light, and the like. The commonly used materials are polyvinyl chloride (PVC), polyvinylidene chloride (PVDC) or composite materials such as PVC/PVDC (polyvinyl chloride/polyvinylidene chloride) composite, PVC/PE (polyvinyl chloride/ (Polyethylene) composites, PVC/PVDC/PE (polyvinyl chloride/polyvinylidene chloride/polyethylene) composites, etc. During the use, it was found that polyvinyl chloride materials are not ideal in terms of moisture resistance and gas barrier of chemicals, and PVDC and its composite materials have been widely used. Compared with the same thickness of material, PVDC has 1500 times more oxygen barrier capacity than PVC, 100 times that of polypropylene (PP), and 100 times that of polyester (PET). It also has superior water vapor and odor resistance properties. In PVC. For example, some use PVC-coated vitamin E capsules, which have been viscous when they have not been used. There are also some proprietary Chinese medicines that require high barrier packaging, especially oxygen-blocking packaging medicines, such as analgesic and anti-inflammatory creams. PVDC membranes are used, and the odor will not be lost and will not affect the efficacy. In addition, the pharmaceutical aluminum foil printing ink should have the characteristics of good adhesion to aluminum foil substrate, good heat resistance, good gloss and no toxicity, etc. At present, the main use of alcohol-soluble polyamide ink and polyvinyl acetate copolymerization Acrylic resin is the main ingredient of aluminum foil ink.

2 Application Status of Other New Flexible Materials for Soft Packaging

条 Strip Packaging SP (Strip Packaging)

It is the use of two layers of medical strip packaging film (SP), the drug sandwiched between a unit of medicine between a certain distance, in the strip packaging machine on the inside of the two layers of SP film heat sealing and sealing, pressure between drugs On the tooth marks, a form of unit packaging? Bar-shaped packaging is continuous operation on the bar-shaped packaging machine, especially for large-volume automatic packaging? When taking drugs, you can tear the SP film along the tooth marks, so take The use of single-dose drugs does not affect the packaging and storage of other drugs. For some larger dosage forms of pharmaceutical packaging, strong hygroscopicity, anti-ultraviolet light, heat and cold resistance are required, and drugs that require a long period of validity can be packaged in this way.

The strip-shaped packaging printing film is an aluminum-plastic composite film having a certain tensile strength and elongation, and is suitable for solid medicines of various shapes and sizes, and is less prone to cracks and wrinkles. The commonly used aluminum-plastic printing composite films are: PT/AL/PE (cellophane/aluminum foil/polyethylene) composite, PET/AL/PE (polyester/aluminum foil/polyethylene) composite, aluminum foil and plastic film to bond The agent is laminated or compounded by extrusion. The internal structure consists of a base layer, a printing layer, a high barrier layer, and a sealing layer. The base layer is outside, the heat seal layer is included, and the high barrier layer and the print layer are in the middle. The base layer material is required to have excellent mechanical properties, luster, good printability, good barrier property, and safety and non-toxicity. The base printing materials used are PET PT and cellophane with PVDC coating. The high barrier layer is good for gas barrier and moisture proof, does not penetrate bacteria and microorganisms, has good mechanical properties, has a certain elongation rate, is resistant to cold, heat, safe and non-toxic, and the typical material used is a soft aluminum foil. This soft aluminum foil is opaque, does not rust, and is highly opaque. If you need a transparent strip packaging film, use PVDC as a high barrier material, which can block gas and water vapor, and can maintain the original taste of the drug well. The sealing layer is the inner layer of the strip packaging film and has excellent heat sealing. Sex, while having chemical stability and hygienic safety, can choose LDPE (low density polyethylene) material. At present, foreign pharmaceutical strip packaging film has developed from double to multi-layer composite.

 ●Aluminum vacuum coating

This material is a flexible packaging film product that evaporates aluminum onto various base films under high vacuum conditions. The aluminum coating is very thin. In the packaging of powders, granules and powders of proprietary Chinese medicines, there are widely used vacuum metallization films such as PETP?CPP?PT?0PP?PE, of which the most widely used is PETP?CPP?PE vacuum aluminum film. In addition to the characteristics of a plastic base film, the vacuum metallized soft film packaging also has beautiful decorative properties and good barrier properties. In particular, after various aluminum substrates are plated with aluminum, their light transmittance, oxygen permeability, and vapor permeability The rate is reduced by tens or hundreds of times. The packaging used for medicines can prevent moldy and damp deterioration of medicines and ensure the safety of consumers' medications.

 ● Biaxially oriented polypropylene (BOPP) film

This kind of film has good transparency, heat resistance and barrier property, and it is used for the outer layer of compound flexible bag for medicines. When it is combined with heat-sealing LDPE and EVA (ethylene copolymer) or aluminum foil, the stiffness and physical properties of the composite film can be greatly improved. For example, if the BOPP base film is coated with PVPC with good moisture-proof and good barrier properties, it can be greatly improved. Improve its anti-permeation properties.

 ● Polyvinylidene chloride (PVDC) film

It is a plastic film printing material with the best barrier properties. Divided into heat-resistant coating film, such as gas barrier PP? CPE (liquid polyethylene), PET and coated PVDC film. The development of a low-priced PVDC coating composite film can be used not only in pharmaceutical packaging, but also in heat-resistant coating packaging for heating foods. The PVDC film is widely used and can be used in natural dairy products. It has oxygen barrier properties and can prevent the mold from producing CO2 during its aging process. At the same time, it can also be designed as a gas barrier PVDC film bag with a pressure reducing valve. It can be used under high temperature and high humidity conditions. It has excellent permeability to oxygen and moisture during transport and storage. PVDC for pharmaceuticals and foods Coated composite film, used in domestic production of high-temperature cooking sterilization bag and preservation bag? Currently including imported PVPC coating film has been widely used in meat, cakes, tea, solid beverage packaging, and to prevent water loss , blocking the gas, maintaining fragrance, antiseptic, preservation and other effects.


 ● Future pharmaceutical flexible packaging printing materials - fluorocarbon halide film

The plastic film is a copolymer of chlorotrifluoroethylene (CTFE). It is non-flammable and has excellent barrier properties. The film has a unique range of applications. There are two types of such films, CTFE and ethylene chlorotrifluoroethylene copolymers. The CTFE film is still soft below -160°C, and its melting point is between 182°C and 204°C, depending on its quality and degree of crystallisation. CTFE is chemically inert and can withstand metals, ceramics and others. Erosion of strong chemicals that plastics cannot withstand? In addition, the CTFE film has a lower water vapor transmission rate than any plastic film, and in fact its hygroscopicity is equal to zero, and it can be compounded with various substrates, such as PE (polyethylene). ) PVC (polyvinyl chloride), PET (polyester), NY (nylon), AL (aluminum foil) composite, etc., can also use vacuum spray aluminum to spray or metallize them? CTFE film and its composites are mainly Used to pack tablets and capsules that require high moisture protection.

The above-mentioned application of the flexible packaging printing material guarantees the barrier properties and safety required for pharmaceutical packaging. Therefore, medicines, tablets, capsules, and proprietary Chinese medicine powders and powders are widely used, and they are promising pharmaceutical flexible packaging printing materials.

Source: Print World

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